●Highly efficient transfection Highly efficient RNA (siRNA, miRNA, mRNA, shRNA) transfection in a wide variety of cells including primary cells and suspension cells.
●Low cytotoxicity. Can be used in serum-containing medium; no medium change is required after transfection.
●High knockdown efficiency, demonstrated in numerous peer-reviewed publications. Here is part of the papers citing use of Engreen RNA transfection reagents.
Front Immunol. 2026 May 29;17:1724930.doi: 10.3389/fimmu.2026.1724930. Machine learning-based identification of an oxidative phosphorylation signature for prognosis, immune infiltration, and drug sensitivity in ovarian cancer.
Biomolecules. 2026 May 19;16(5):741.doi: 10.3390/biom16050741. Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm
J Nutr Biochem. 2026 May:151:110261.doi: 10.1016/j.jnutbio.2026.110261. Epub 2026 Jan 6. Dietary phospholipids alleviate high fat diet-induced intestinal lipid deposition through ATF4-PPARα-MTTP/SAR1B pathway in yellow catfish
FASEB J. 2026 May 15;40(9):e71855.doi: 10.1096/fj.202503895RR. High-Fat Diet Induces Inflammatory Injury in Mice Sertoli Cells via the IRE1α/TRAF2 Axis to Activate the NF-κB Signaling Pathway
Cell Calcium. 2026 Apr 19:135:103137.doi: 10.1016/j.ceca.2026.103137. TRPC1 channel modulates mechanical stretch-induced bone marrow mesenchymal stem cell proliferation through Ca2+-dependent ERK1/2 activation
Int J Radiat Oncol Biol Phys. 2026 Apr 5:S0360-3016(26)00521-3.doi: 10.1016/j.ijrobp.2026.03.037. Alternative End Joining Dependency Imposed by miR-21-5p Defines Radiation Resistance and a Targetable Vulnerability in Oral Squamous Cell Carcinoma
Pharmaceuticals (Basel). 2026 Mar 27;19(4):540.doi: 10.3390/ph19040540. Identification of Dopamine D2 Receptor as a Direct Target of Salidroside and Tyrosol by Integrated Transcriptomic and Biophysical Approaches
Viruses. 2026 Mar 5;18(3):323.doi: 10.3390/v18030323. Tree Shrew Genome-Wide CRISPR Screen Identifies RNF6 as a Proviral Host Factor for Zika Virus Replication in Brain Microvascular Endothelial Cells
Arthritis Res Ther. 2026 Feb 12;28(1):69.doi: 10.1186/s13075-026-03762-5.The inhibition of miR-125b-5P prevented Treg differentiation through activating STAT3/HIF-1α pathway in PBMCs of ankylosing spondylitis
Phytomedicine. 2026 Feb:151:157811.doi: 10.1016/j.phymed.2026.157811. Epub 2026 Jan 7. Single-nucleus analysis reveals Dengzhan Shengmai capsule prevents cardiac fibrosis after myocardial infarction in rat by targeting Ltbp2+ fibroblast subset
Biochem Pharmacol. 2026 Jan 20:246:117723.doi: 10.1016/j.bcp.2026.117723. Small nucleolar RNA host gene 3 regulates sepsis-induced acute lung injury and inflammation by targeting microRNA-186-5p
Hereditas. 2025 Dec 6;163(1):10.doi: 10.1186/s41065-025-00618-x. The diagnostic value and mechanism of miR-127-3p in type 2 diabetes and complications of diabetic nephropathy.
J Nutr Biochem. 2025 Nov:145:110033.doi: 10.1016/j.jnutbio.2025.110033. Epub 2025 Jul 14. Oxidative stress and caspase 3/Gsdme-dependent pyroptosis contributes to high fat diet induced-intestinal inflammation and lipotoxicity via Srebp1 cleavage at D444 site by
Autoimmunity. 2025 Dec;58(1):2576881.doi: 10.1080/08916934.2025.2576881. High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell
Environ Health (Wash). 2025 Nov 4;4(3):473-487.doi: 10.1021/envhealth.5c00261. FTO-ACKR3 Axis Regulates Polycyclic Aromatic Hydrocarbons-Induced Asthma Attacks via AhR-Mediated m6A RNA Methylation
BMC Cancer. 2025 Oct 10;25(1):1553.doi: 10.1186/s12885-025-14854-x. PCBP1-AS1 facilitates liver metastasis in pancreatic cancer by modulating miR-125b-5p in Tumor-derived exosomes to target TNFAIP3
Sci Rep. 2025 Oct 8;15(1):35186.doi: 10.1038/s41598-025-19169-2. PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway
Cell Mol Immunol. 2025 Aug 20.doi: 10.1038/s41423-025-01331-5. SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target
Cell Biochem Biophys. 2025 Jul 28.doi: 10.1007/s12013-025-01782-7. FABP4 Downregulated by FOS Alleviates Palmitic Acid-induced Endothelial Cell Dysfunction Via Inactivating ERK/STAT-1 Signaling Pathway
Ann Med. 2025 Dec;57(1):2530690.doi: 10.1080/07853890.2025.2530690. Epub 2025 Jul 11. MiR-223-3p regulates erythropoiesis by targeting TGFBR3/Smad signaling pathway in hemoglobin H-Constant Spring disease
Int J Mol Sci. 2025 Jun 16;26(12):5766.doi: 10.3390/ijms26125766. Advances in Regenerative Therapies for Inflammatory Arthritis: Exploring the Potential of Mesenchymal Stem Cells and Extracellular Vesicles
Alzheimers Dement. 2025 Jun 1;21(6):e70369.doi: 10.1002/alz.70369. TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice.
Front Endocrinol (Lausanne). 2025 May 2:16:1556310.doi: 10.3389/fendo.2025.1556310. eCollection 2025. Ameliorative effect and potential mechanism of hyperoside on diabetic retinopathy
3 Biotech. 2025 Apr;15(4):79.doi: 10.1007/s13205-025-04231-7. Epub 2025 Mar 8. POGZ targeted by LINC01355/miR-27b-3p retards thyroid cancer progression via interplaying with MAD2L2
Sci Rep. 2025 Mar 18;15(1):9225.doi: 10.1038/s41598-025-93081-7. ITGB5 is a prognostic factor in colorectal cancer and promotes cancer progression and metastasis through the Wnt signaling pathway
Cell Commun Signal. 2025 Feb 1;23(1):59.doi: 10.1186/s12964-025-02038-w. Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with X1X1X2X2/X1X2Y chromosome system
Cancer Cell Int. 2025 Jan 13;25(1):10.doi: 10.1186/s12935-025-03638-9.Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation
Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167498.doi: 10.1016/j.bbadis.2024.167498. Epub 2024 Sep 5. S100A4 mediates the accumulation and functions of myeloid-derived suppressor cells via GP130/JAK2/STAT3 signaling in acute myeloid leukemia
Cardiovasc Diabetol. 2024 Dec 21;23(1):452.doi: 10.1186/s12933-024-02545-z. ANXA1-FPR2 axis mitigates the susceptibility to atrial fibrillation in obesity via rescuing AMPK activity in response to lipid overload
Front Pharmacol. 2024 Dec 18:15:1464852.doi: 10.3389/fphar.2024.1464852. eCollection 2024. Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC
J Gen Virol. 2024 Dec;105(12).doi: 10.1099/jgv.0.002058. Role of ubiquitin-proteasome pathway in budded virus egress and GP64 surface distribution in Bombyx mori nucleopolyhedrovirus
Mol Neurobiol. 2024 Dec;61(12):10770-10791.doi: 10.1007/s12035-024-04251-z. Epub 2024 May 24. Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer’s Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA and Regulating STAT3 Phosphorylation
Biochem Biophys Res Commun. 2024 Dec 3:736:150499.doi: 10.1016/j.bbrc.2024.150499. Epub 2024 Aug 3. The uncleaved signal peptide of Bombyx mori nucleopolyhedrovirus GP64 preferentially activates BmSpz7 expression, contributing to protein secretion
J Thorac Dis. 2024 Nov 30;16(11):7709-7728.doi: 10.21037/jtd-24-680. Epub 2024 Nov 14. Exacerbation of pulmonary fibrosis following acute lung injury via activin-A production by recruited alveolar macrophages
Mol Med Rep. 2024 Nov 22;31(2):31.doi: 10.3892/mmr.2024.13397. MDM2 interacts with PTEN to inhibit endothelial cell development and promote deep vein thrombosis via the JAK/STAT signaling pathway.
J Cell Mol Med. 2024 Nov;28(21):e70167.doi: 10.1111/jcmm.70167. Potential pro-tumour cytokine in oral squamous cellular carcinoma: IL37
Redox Biol. 2024 Nov:77:103395.doi: 10.1016/j.redox.2024.103395. Epub 2024 Oct 15. Diallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling
Cell Mol Life Sci. 2024 Oct 5;81(1):422.doi: 10.1007/s00018-024-05452-4. SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus
Cell Biochem Biophys. 2024 Sep 22.doi: 10.1007/s12013-024-01530-3. Inhibition of FABP4 Ameliorates IL-13-Induced Inflammatory Response and Barrier Dysfunction in Nasal Mucosal Epithelial Cells through the Regulation of Ferroptosis
Biochim Biophys Acta Gene Regul Mech. 2024 Sep;1867(3):195041.doi: 10.1016/j.bbagrm.2024.195041. Epub 2024 May 11. Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco)
Cell Biochem Biophys. 2024 Sep;82(3):2171-2181.doi: 10.1007/s12013-024-01324-7. Epub 2024 May 29. Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury
Genet Test Mol Biomarkers. 2024 Aug;28(8):311-321.doi: 10.1089/gtmb.2023.0531. Epub 2024 Jul 18. METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That Promotes Cancer Cell Proliferation by Interacting with IGF2BP3
Biologics. 2024 Jul 4:18:181-193.doi: 10.2147/BTT.S461287. eCollection 2024. STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression
J Cell Biochem. 2024 May;125(5):e30551.doi: 10.1002/jcb.30551. Epub 2024 Mar 11. Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator
Int Immunopharmacol. 2024 Apr 20:131:111785.doi: 10.1016/j.intimp.2024.111785. Epub 2024 Mar 12. Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p/HO-1/NLRP3 axis modulation
J Cancer. 2024 Apr 8;15(10):3114-3127.doi: 10.7150/jca.93833. Inhibition of esophageal cancer progression through HACE1-TRIP12 interaction and associated RAC1 ubiquitination and degradation.
Int Immunopharmacol. 2024 Apr 20:131:111864.doi: 10.1016/j.intimp.2024.111864. Epub 2024 Mar 13. miR-186-5p improves alveolar epithelial barrier function by targeting the wnt5a/β-catenin signaling pathway in sepsis-acute lung injury
J Exp Clin Cancer Res. 2024 Apr 23;43(1):123.doi: 10.1186/s13046-024-03048-1. Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression
Int Immunopharmacol. 2024 Mar 30:130:111685.doi: 10.1016/j.intimp.2024.111685. Epub 2024 Feb 20. Inhibition of CISD1 alleviates mitochondrial dysfunction and ferroptosis in mice with acute lung injury
Reprod Biol. 2024 Mar 7;24(2):100876.doi: 10.1016/j.repbio.2024.100876. Online ahead of print. Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis
Reprod Biol. 2024 Mar;24(1):100841.doi: 10.1016/j.repbio.2023.100841. Epub 2023 Dec 19. Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts
Environ Toxicol. 2024 Mar 13.doi: 10.1002/tox.24200. Online ahead of print. Exploration of immune cell heterogeneity by single-cell RNA sequencing and identification of secretory leukocyte protease inhibitor as an oncogene in pancreatic cancer
J Cancer. 2024 Mar 11;15(9):2561-2572.doi: 10.7150/jca.92386. USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination.
Exp Brain Res. 2024 Jan;242(1):33-45.doi: 10.1007/s00221-023-06682-x. Epub 2023 Nov 6. MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage
J Assist Reprod Genet. 2024 Jan 25.doi: 10.1007/s10815-024-03034-8. Online ahead of print. Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation
J Physiol. 2024 Jan;602(2):317-332.doi: 10.1113/JP283960. Epub 2023 Dec 28. miR-22-3p in the rostral ventrolateral medulla promotes hypertension through inhibiting β-arrestin-1
Comp Biochem Physiol B Biochem Mol Biol. 2024 Jan:269:110894.doi: 10.1016/j.cbpb.2023.110894. Epub 2023 Aug 18. SIRT1-NRF2-TFEB axis-mediated hepatic lipophagy alleviates the lipid deposition induced by high glucose in yellow catfish Pelteobagrus fulvidraco
Front Immunol. 2024 Jan 4;14:1272108.doi: 10.3389/fimmu.2023.1272108. A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.
J Nutr Biochem. 2023 Dec 28:126:109559.doi: 10.1016/j.jnutbio.2023.109559. Online ahead of print. Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain
Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):143-149.doi: 10.14715/cmb/2023.69.14.23. Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells
Pharm Biol. 2023 Dec;61(1):1-11.doi: 10.1080/13880209.2022.2099430. The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway
Chemosphere. 2023 Dec:345:140428.doi: 10.1016/j.chemosphere.2023.140428. Epub 2023 Oct 17. Organic anion transporting polypeptide 3a1 is a novel influx pump for Perfluorooctane sulfonate in Sertoli cells and contributes to its reproductive toxicity
J Nutr Biochem. 2023 Nov:121:109429.doi: 10.1016/j.jnutbio.2023.109429. Epub 2023 Aug 15. Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of β-catenin at lysine 311
Exp Ther Med. 2023 Nov 9;27(1):6.doi: 10.3892/etm.2023.12293. MicroRNA‑155‑5p affects regulatory T cell activation and immunosuppressive function by targeting BCL10 in myasthenia gravis.
Environ Pollut. 2023 Nov 1:336:122416.doi: 10.1016/j.envpol.2023.122416. Epub 2023 Aug 18. MnO2 nanoparticles and MnSO4 differentially affected hepatic lipid metabolism through miR-92a/acsl3-dependent de novo lipogenesis in yellow catfish Pelteobagrusfulvidraco
Pulm Pharmacol Ther. 2023 Oct:82:102244.doi: 10.1016/j.pupt.2023.102244. Epub 2023 Jul 25. SIRT3 alleviates sepsis-induced acute lung injury by inhibiting pyroptosis via regulating the deacetylation of FoxO3a
J Cell Mol Med. 2023 Sep;27(18):2730-2743.doi: 10.1111/jcmm.17860. Epub 2023 Jul 21. The role of PKN1 in glioma pathogenesis and the antiglioma effect of raloxifene targeting PKN1
PLoS One. 2023 Sep 12;18(9):e0291469.doi: 10.1371/journal.pone.0291469. Fucoxanthin inhibits cardiac fibroblast transdifferentiation by alleviating oxidative stress through downregulation of BRD4.
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Biochim Biophys Acta Gene Regul Mech. 2022 Oct;1865(7):194874.doi: 10.1016/j.bbagrm.2022.194874. Epub 2022 Sep 16. Dietary choline prevents high fat-induced disorder of hepatic cholesterol metabolism through SREBP-2/HNF-4α/CYP7A1 pathway in a freshwater teleost yellow catfish Pelteobagrus fulvidraco
Open Life Sci. 2022 Oct 12;17(1):1324-1332.doi: 10.1515/biol-2022-0491. eCollection 2022. S1P promotes corneal trigeminal neuron differentiation and corneal nerve repair via upregulating nerve growth factor expression in a mouse model
Vet Sci. 2022 Sep 28;9(10):531.doi: 10.3390/vetsci9100531. Effect and Mechanism of siRNAs Targeting IL-1β/TNF-α Combined with BMSCs Transplantation in Ameliorating Rheumatoid Arthritis in Rats
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Antioxid Redox Signal. 2022 Sep;37(7-9):417-436.doi: 10.1089/ars.2021.0190. Epub 2022 Jul 12. Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1
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Cell Cycle. 2022 Aug;21(15):1557-1577.doi: 10.1080/15384101.2022.2057633. Epub 2022 Apr 9. Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184
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Am J Transl Res. 2022 Jun 15;14(6):4295-4309. PKC inhibitors regulate stem cell self-renewal by regulating H3K27me3 and H3K9me3.
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Bioengineered. 2022 May;13(5):11503-11516.doi: 10.1080/21655979.2022.2068737. (IF3.269) TNF-like weak inducer of apoptosis / nuclear factor κB axis feedback loop promotes spinal cord injury by inducing astrocyte activation
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Environ Pollut. 2022 May 15:301:118960.doi: 10.1016/j.envpol.2022.118960. Epub 2022 Feb 9. Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal/miR-9-3p downregulating StAR expression in Leydig cells
Nucleic Acids Res. 2022 May 6;50(8):e46.doi: 10.1093/nar/gkac014. A Cas6-based RNA tracking platform functioning in a fluorescence-activation mode
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Stem Cell Res Ther. 2022 Apr 8;13(1):149.doi: 10.1186/s13287-022-02823-1. Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF
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Mol Biotechnol.2022 Jan 22.doi: 10.1007/s12033-022-00452-w.l Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression
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ACS Appl Mater Interfaces. 2022 Jan 12;14(1):307-323.doi: 10.1021/acsami.1c20053. Epub 2021 Dec 30. Dual-Regulated Functionalized Liposome-Nanoparticle Hybrids Loaded with Dexamethasone/TGFβ1-siRNA for Targeted Therapy of Glomerulonephritis
Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1;1868(1):166268.doi: 10.1016/j.bbadis.2021.166268. Epub 2021 Sep 16. GPX1-associated prognostic signature predicts poor survival in patients with acute myeloid leukemia and involves in immunosuppression
Aging (Albany NY). 2021 Dec 30;13(24):26095-26117.doi: 10.18632/aging.203799. Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors.
Cell Death Dis. 2021 Dec 11;12(12):1149.doi: 10.1038/s41419-021-04445-6. CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice
Front Genet. 2021 Oct 18;12:738559.doi: 10.3389/fgene.2021.738559. MiR-320d Inhibits Progression of EGFR-Positive Colorectal Cancer by Targeting TUSC3.
Cancer Gene Ther. 2021 Jun;28(6):667-678.doi:10.1038/s41417-020-00247-8. Epub 2020 Oct 27. circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2
Exp Ther Med.2021 Nov;22(5):1321.doi: 10.3892/etm.2021.10756.Epub 2021 Sep 20.Gas6/Axl signaling pathway promotes proliferation, migration and invasion and inhibits apoptosis in A549 cells.
Exp Ther Med. 2021 Sep 16;22(5):1311.doi: 10.3892/etm.2021.10746. Blocking tumor necrosis factor-α delays progression of chronic obstructive pulmonary disease in rats through inhibiting MAPK signaling pathway and activating SOCS3/TRAF1.
Dig Dis Sci. 2021 Sep;66(9):3036-3044.doi:10.1007/s10620-020-06640-5. Epub 2020 Oct 22.Knockdown of Bcl-2-Associated Athanogene-3 Can Enhance the Efficacy of BGJ398 via Suppressing Migration and Inducing Apoptosis in Gastric Cancer
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J Invertebr Pathol. 2021Sep;184:107647.doi:10.1016/j.jip.2021.107647. Epub 2021 Jul 23.Bombyx mori Apolipophorin-III inhibits Beauveria bassiana directly and through regulating expression of genes relevant to immune signaling pathways
Adv Clin Exp Med. 2021 Aug;30(8):779-788.doi: 10.17219/acem/135937. MiR-let-7i inhibits CD4+ T cell apoptosis in patients with acute coronary syndrome
Front Physiol. 2021 Aug 4;12:663482.doi:10.3389/fphys.2021.663482. eCollection 2021. Two Putative Cypovirus-Encoded miRNAs Co-regulate the Host Gene of GTP-Binding Nuclear Protein Ran and Facilitate Virus Replication
Front Immunol. 2020 Jun 11;11:1195.doi:10.3389/fimmu.2020.01195. eCollection 2020. Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto’s Thyroiditis
Brain Behav. 2020 Jun;10(6):e01627.doi: 10.1002/brb3.1627. Epub 2020 Apr 19.Mechanism of microRNA-22 in regulating neuroinflammation in Alzheimer’s disease
Front Immunol. 2021 May 19;12:668760.doi: 10.3389/fimmu.2021.668760. Resolvin D1 Improves the Treg/Th17 Imbalance in Systemic Lupus Erythematosus Through miR-30e-5p.
J Transl Med. 2021 May 26;19(1):223.doi:10.1186/s12967-021-02893-4. miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis
Oncol Rep. 2021 Apr 13;45(6):95.doi: 10.3892/or.2021.8046. Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway.
Vet Microbiol. 2020 Mar;242:108610.doi:10.1016/j.vetmic.2020.108610. Epub 2020 Feb 10.Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection
Front Immunol. 2021 Mar 18;12:626310.doi:10.3389/fimmu.2021.626310. eCollection 2021. Adiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis
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Front Med (Lausanne). 2021 Feb 19;8:630962.doi: 10.3389/fmed.2021.630962. Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
J Extracell Vesicles. 2021 Feb 18;10(4):e12068.doi: 10.1002/jev2.12068. Small extracellular vesicles deliver osteolytic effectors and mediate cancer-induced osteolysis in bone metastatic niche.
Am J Transl Res. 2021 Feb 15;13(2):672-683. POU2F1 induces the immune escape in lung cancer by up-regulating PD-L1.
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Curr Microbiol. 2021 Feb;78(2):490-501.doi: 10.1007/s00284-020-02309-4. Epub 2021 Jan 2. 18 Additional Amino Acids of the Signal Peptide of the Bombyx mori Nucleopolyhedrovirus GP64 Activates Immunoglobulin Binding Protein (BiP) Expression by RNA-seq Analysis
Theranostics. 2021 Jan 1;11(2):893-905.doi: 10.7150/thno.48080. eCollection 2021. Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
Life Sci. 2021 Jan 1;264:118687.doi: 10.1016/j.lfs.2020.118687. Epub 2020 Nov 9.PGRN -/- TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism explorationTAMs
Toxicol Appl Pharmacol. 2021 Jan 1;410:115336.doi:10.1016/j.taap.2020.115336. Epub 2020 Nov 17.Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism
J Exp Clin Cancer Res. 2021 Jan 4;40(1):4.doi: 10.1186/s13046-020-01786-6. Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion
Mol Med Rep. 2020 Dec 23;23(2):154.doi: 10.3892/mmr.2020.11793. MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Int J Mol Med.2020 Dec;46(6):2172-2184.doi: 10.3892/ijmm.2020.4755. Epub 2020 Oct 13.Long non-coding RNA expression profiles identify lncRNA-XLOC_I2_006631 as a potential novel blood biomarker for Hashimoto’s thyroiditis.
Mol Nutr Food Res. 2020 Dec;64(23):e2000383.doi: 10.1002/mnfr.202000383. Epub 2020 Nov 9. Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6
J Recept Signal Transduct Res. 2020 Dec;40(6):550-559.doi:10.1080/10799893.2020.1768547. Epub 2020 Jun 1. Antagonizing effect of icaritin on apoptosis and injury of hippocampal neurocytes induced by amyloid beta via GR/BDNF signaling pathway
Neurochem Res. 2020 Dec;45(12):3045-3058.doi:10.1007/s11064-020-03152-6. Epub 2020 Oct 23. CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke
Sci Rep.2020 Oct 27;10(1):18303.doi: 10.1038/s41598-020-75358-1.MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell.
J Cancer.2020 Feb 3;11(8):2222-2233.doi: 10.7150/jca.39679. eCollection 2020. The Role of MiR-5094 as a Proliferation Suppressor during Cellular Radiation Response via Downregulating STAT5b.
Immunol Lett. 2020 Sep;225:44-49.doi: 10.1016/j.imlet.2020.06.009. Epub 2020 Jun 15. Yes-associated protein upregulates filopodia formation to promote alveolar epithelial-cell phagocytosis
Mol Ther. 2020 Sep 6;28(11):2442-2457.doi: 10.1016/j.ymthe.2020.09.010. Lactate Induces Production of the tRNA<sup>His</sup> Half to Promote B-lymphoblastic Cell Proliferation.
Mamm Genome.2020 Aug;31(7-8):197-204.doi: 10.1007/s00335-020-09842-4. Epub 2020 Jun 15.ryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer
Oncol Lett. 2020 Jul 29;20(4):68.doi: 10.3892/ol.2020.11929. Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels.
J Cell Mol Med. 2020 Jun 10;24(14):8078-8090.doi: 10.1111/jcmm.15439. New mechanism of nerve injury in Alzheimer’s disease: β-amyloid-induced neuronal pyroptosis.
Cell Stress Chaperones.2020 May;25(3):395-406.doi: 10.1007/s12192-020-01079-z.Epub 2020 Mar 2.Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation
Glia. 2020 Nov;68(11):2415-2426.doi: 10.1002/glia.23850. Epub 2020 May 27.Activation of astrocytic sigma-1 receptor exerts antidepressant-like effect via facilitating CD38-driven mitochondria transfer
Cell Death Dis.2020 Apr 27;11(4):293.doi: 10.1038/s41419-020-2496-y.CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells.
Mol Carcinog.2020 May;59(5):557-568.doi: 10.1002/mc.23180.Epub 2020 Mar 11.XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the proliferation and metastasis of non-small-cell lung cancer cells.
J Nutr.2020 Mar 1;150(3):464-474.doi:10.1093/jn/nxz282.miR-144 Mediates High Fat-Induced Changes of Cholesterol Metabolism via Direct Regulation of C/EBPα in the Liver and Isolated Hepatocytes of Yellow Catfish
J Immunol Res.2020 Jan 30;2020:6401978.doi: 10.1155/2020/6401978. eCollection 2020.Elevated Expression of the Long Noncoding RNA IFNG-AS1 in the Peripheral Blood from Patients with Rheumatoid Arthritis
Biochim Biophys Acta Mol Basis Dis. 2019 Dec 1;1865(12):165540. doi: 10.1016/j.bbadis.2019.165540. Epub 2019 Aug 27.
G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses.
Cell Cycle.2019 Oct;18(19):2432-2446.doi: 10.1080/15384101.2019.1648956.Epub 2019 Aug 25.lvement of FBP1 in prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by regulating the MAPK signaling pathway
Sci Rep.2019 Nov 22;9(1):17417.doi: 10.1038/s41598-019-53870-3.GF/Flk1 Mechanism is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis.
Mol Ther Nucleic Acids. 2019 Sep 6;17:38-48. doi: 10.1016/j.omtn.2019.05.004. Epub 2019 May 22.
Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto’s Thyroiditis via Sponging miR125a-3p.
Biosci Rep . 2019 Aug 19;39(8):BSR20190109. doi: 10.1042/BSR20190109. Print 2019 Aug 30. Liraglutide Inhibits the Apoptosis of Human Nucleus Pulposus Cells Induced by High Glucose Through PI3K/Akt/caspase-3 Signaling Pathway
Biosci Rep. 2019 Aug 19;39(8). pii: BSR20190109. doi: 10.1042/BSR20190109. Print 2019 Aug 30.
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.
J Autoimmun. 2019 Aug;102:96-113. doi: 10.1016/j.jaut.2019.04.018. Epub 2019 May 23.
NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3.
Cancer Lett. 2019 May 28;450:110-122. doi: 10.1016/j.canlet.2019.02.029. Epub 2019 Feb 18.
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.
Chemosphere. 2019 May;223:165-170. doi: 10.1016/j.chemosphere.2019.01.169. Epub 2019 Feb 1.
Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.
Leuk Lymphoma. 2019 Mar;60(3):772-781. doi: 10.1080/10428194.2018.1493727. Epub 2019 Jan 15.
Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma.
Eur Rev Med Pharmacol Sci.2019 Apr;23(8):3291-3301.doi: 10.26355/eurrev_201904_17691.Increased long noncoding RNA LINC00511 is correlated with poor prognosis and contributes to cell proliferation and metastasis by modulating miR-424 in hepatocellular carcinoma.
Mol Cancer. 2019 Mar 30;18(1):61. doi: 10.1186/s12943-019-0978-2.
Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.
Int J Mol Med. 2018 Jun;41(6):3379-3393. doi: 10.3892/ijmm.2018.3526. Epub 2018 Mar 1.
MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway.
Eur Rev Med Pharmacol Sci. 2018 May;22(9):2572-2579.doi: 10.26355/eurrev_201805_14950. Overexpression of PER3 reverses paclitaxel resistance of prostate cancer cells by inhibiting the Notch pathway
J Virol. 2018 Apr 13;92(9). pii: e00033-18. doi: 10.1128/JVI.00033-18. Print 2018 May 1.
Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth.
Mol Med Rep. 2018 Apr;17(4):5851-5859. doi: 10.3892/mmr.2018.8601. Epub 2018 Feb 13.
Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells.
Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1297-1306.doi: 10.26355/eurrev_201803_14471. LncRNA SNHG12 regulated the proliferation of gastric carcinoma cell BGC-823 by targeting microRNA-199a/b-5p LncRNA-SNGG12
Biofactors. 2018 Mar;44(2):123-136. doi: 10.1002/biof.1395. Epub 2017 Nov 29.
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells.
Exp Cell Res. 2017 Dec 15;361(2):342-352.doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.
Exp Cell Res. 2017 Dec 15;361(2):342-352. doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.
Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5661-5667.doi: 10.26355/eurrev_201712_14010. High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer lnc-CRNDE
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A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.
J Exp Clin Cancer Res. 2016 Sep 17;35(1):145. doi: 10.1186/s13046-016-0423-y.
Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.
J Orthop Translat. 2016 Jun 8;7:1-6. doi: 10.1016/j.jot.2016.05.011. eCollection 2016 Oct.
Knockdown of asporin affects transforming growth factor-β1-induced matrix synthesis in human intervertebral annulus cells.
Immunol Res. 2016 Apr;64(2):489-96. doi: 10.1007/s12026-015-8715-4.
Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome.
Stem Cells Dev. 2016 Mar 15;25(6):477-91. doi: 10.1089/scd.2015.0301. Epub 2016 Feb 22.
High-Efficient Transfection of Human Embryonic Stem Cells by Single-Cell Plating and Starvation.
Mol Med Rep. 2016 Mar;13(3):2492-8. doi: 10.3892/mmr.2016.4814. Epub 2016 Jan 27.
Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2.
Int J Mol Med. 2015 Dec;36(6):1497-506. doi: 10.3892/ijmm.2015.2363. Epub 2015 Oct 9.
miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells.
Mol Biosyst. 2015 Nov;11(11):3040-7. doi: 10.1039/c5mb00347d.
The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway.
Tumour Biol. 2016 Mar;37(3):3479-88. doi: 10.1007/s13277-015-4086-7. Epub 2015 Oct 9.
MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2.
Endocrine. 2015 Aug;49(3):752-60.doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
MiR-346 regulates CD4+CXCR5 + T cells in the pathogenesis of Graves’ disease.
Endocrine. 2015 Aug;49(3):752-60. doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves’ disease.
J Immunol. 2015 Aug 1;195(3):1301-11. doi: 10.4049/jimmunol.1500209. Epub 2015 Jun 19.
MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.
Immunol Res. 2015 Jun;62(2):129-36. doi: 10.1007/s12026-015-8643-3.
Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis.
PLoS One. 2015 Mar 31;10(3):e0121510. doi: 10.1371/journal.pone.0121510. eCollection 2015.
MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.
Apoptosis. 2015 Jan;20(1):92-109. doi: 10.1007/s10495-014-1058-0.
RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells.
Mol Biosyst. 2014 Apr;10(4):759-66. doi: 10.1039/c3mb70391f. Epub 2014 Jan 23.
Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins.
Apoptosis. 2013 Nov;18(11):1348-1362. doi: 10.1007/s10495-013-0866-y.
The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.
Int J Nanomedicine . 2013;8:3805-16. doi: 10.2147/IJN.S48950. Epub 2013 Oct 2. Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-α and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Matrix Biol. 2013 Jun 24;32(5):265-76.doi: 10.1016/j.matbio.2013.02.004. Epub 2013 Mar 5.
Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment.
Cell Signal. 2013 Jun;25(6):1526-38. doi: 10.1016/j.cellsig.2012.12.025. Epub 2013 Jan 16.
SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.
J Immunol. 2013 Mar 1;190(5):2437-46. doi: 10.4049/jimmunol.1202282. Epub 2013 Jan 25.
Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways.
Respir Physiol Neurobiol. 2013 Jan 15;185(2):332-8. doi: 10.1016/j.resp.2012.09.009. Epub 2012 Oct 8.
Effect of annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells.
Genes Immun. 2012 Dec;13(8):621-31. doi: 10.1038/gene.2012.45. Epub 2012 Oct 4.
TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7.
Cytokine. 2012 Nov;60(2):505-13. doi: 10.1016/j.cyto.2012.06.317. Epub 2012 Jul 31.
BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells.
Biochem J. 2012 Nov 1;447(3):407-16. doi: 10.1042/BJ20120256.
Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.
J Cell Sci. 2012 Sep 15;125(Pt 18):4219-29. doi: 10.1242/jcs.086553. Epub 2012 May 28.
Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.
J Radiat Res. 2012 Jul;53(4):516-25. doi: 10.1093/jrr/rrs002. Epub 2012 Jun 6.
MicroRNA-148b enhances the radiosensitivity of non-Hodgkin’s Lymphoma cells by promoting radiation-induced apoptosis.
Genes Immun. 2012 Jun;13(4):311-20. doi: 10.1038/gene.2011.87. Epub 2012 Jan 26.
Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments.
Cell Biochem Funct. 2012 Mar;30(2):108-13. doi: 10.1002/cbf.1823. Epub 2011 Oct 26.
The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells.
Virus Res. 2012 Jan;163(1):183-9. doi: 10.1016/j.virusres.2011.09.016. Epub 2011 Sep 16.
Small interfering RNA against the 2C genomic region of coxsackievirus B3 exerts potential antiviral effects in permissive HeLa cells.
J Sex Med. 2011 Oct;8(10):2773-80. doi: 10.1111/j.1743-6109.2011.02412.x. Epub 2011 Aug 5.
Up-regulation of VEGF by small activator RNA in human corpus cavernosum smooth muscle cells.
J Immunol. 2011 Apr 15;186(8):4716-24. doi: 10.4049/jimmunol.1002989. Epub 2011 Mar 7.
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
Microvasc Res. 2010 Jul;80(1):158-65. doi: 10.1016/j.mvr.2010.01.003. Epub 2010 Jan 14.
A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.
Apoptosis. 2010 Apr;15(4):488-98. doi: 10.1007/s10495-009-0439-2.
A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats.
J Biol Chem. 2010 Apr 2;285(14):10890-901. doi: 10.1074/jbc.M109.058347. Epub 2010 Jan 26.
Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.
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